C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01) C07D 237/04 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2588947
The present invention provides compounds of formula (I) possessing inhibitory activity against ~ adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
La présente invention se rapporte à des composés présentant une activité inhibitrice dirigée contre les récepteurs bêta-adrénergiques et la phosphodiestérase (PDE), notamment la phosphodiestérase de type 3 (PDE-3). La présente invention a également trait à des compositions pharmaceutiques contenant de tels composés, à des procédés de préparation de tels composés, et à des procédés d'utilisation de tels composés permettant de réguler l'homéostasie calcique, de traiter une maladie, un trouble ou un état pathologique mettant en jeu la dérégulation de l'homéostasie calcique, et de traiter des maladies cardiovasculaires, l'accident vasculaire cérébral, l'épilepsie, des troubles ophtalmiques ou la migraine.
Klenke Burkhard
Mazhari Reza
Suzdak Peter D.
Taylor Malcolm George
Artesian Therapeutics Inc.
Mccarthy Tetrault Llp
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