C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/4704 (2006.01) C07D 215/227 (2006.01) C07D 233/70 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2511496
The present invention provides compounds possessing inhibitory activity against (3-adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
La présente invention concerne des composés qui possèdent une activité inhibitrice sur des récepteurs adrénergiques .beta. et la phosphodiestérase (PDE), notamment, la phosphodiestérase de type 3 (PDE-3). Cette invention a aussi trait à des compositions pharmaceutiques renfermant de tels composés, à des méthodes de préparation de ces composés, et à des méthodes d'utilisation desdits composés afin de réguler une homéostase du calcium, de traiter une maladie, un trouble ou un état dans lequel est impliqué un dérèglement de l'homéostase du calcium, et de traiter une maladie cardio-vasculaire, un accident vasculaire cérébral, une crise d'épilepsie, un trouble ophtalmique ou une migraine.
Hamilton Gregory S.
Leighton Harry Jefferson
Artesian Therapeutics Inc.
Mccarthy Tetrault Llp
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