Cardiotrophin and uses therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/08 (2006.01) A61K 35/34 (2006.01) A61K 38/19 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2245635

Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. CT-1 is shown to bind to and activate the receptor, LIFR.beta.. These CT-1 molecules are shown to influence hypertrophic activity, neurological activity, and other activities associated with receptor LIFR.beta.. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, neurological disorders, and other disorders associated with the LIFR.beta..

CT-1 isolée, ADN isolé codant cette CT-1 et méthodes d'élaboration par recombinaison ou par synthèse de cette CT-1. La CT-1 est connue pour se lier au récepteur LIFR.beta. et pour l'activer. Ces molécules CT-1 sont connues pour exercer une influence sur l'activité hypertrophique, l'activité neurologique et d'autres activités liées au récepteur LIFR.beta.. En conséquence, ces composés ou leurs antagonistes peuvent être utilisés pour le traitement de l'insuffisance cardiaque, des troubles arythmiques, inotropes et neurologiques ou autres associés au récepteur LIFR.beta..

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