Cardiotrophin and uses therefor

Details Cardiotrophin and uses therefor Cardiotrophin and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07H 21/04 (2006.01) C07K 1/22 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188017

Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

L'invention porte sur l'isolement du facteur d'hypertrophie cardiaque (CHF également appelé cardiotrophine), sur l'ADN isolé codant le CHF, et sur des procédés de préparation du CHF par recombinaison ou par synthèse. Les molécules de CHF, ou leurs antagonistes, qui s'avèrent influencer l'activité hypertrophique et neurologique, peuvent donc être utilisées pour traiter l'insuffisance cardiaque, l'arythmie et les troubles inotropes et neurologiques.

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