A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01)
Patent
CA 2227038
Cardiotropic radiopharmaceuticals comprising a transition metal nitride complex and having rapid myocardial clearance are disclosed. The complexes have formula (I): (MN)L<1> L<2>, wherein M is a transition metal such as: <99m>Tc, and L<1> and L<2> have formula (II), wherein at least one of R and R' is a branched alkyl group comprising one or more ether functions, a tetrahydrofurfuryl or ether group or a tetrahydrofurfuryl or dioxaspiro or dialkoxy piperidino type group.
L'invention concerne des produits radiopharmaceutiques à tropisme cardiaque comportant un complexe nitruro d'un métal de transition et ayant une clairance myocardique rapide. Ces complexes répondent à la formule (I): (M N) L1 L2 dans laquelle M est un métal de transition tel que 99mTc, et L1 et L2 répondent à la formule (II), dans laquelle au moins l'un des R et R' représente un groupe alkyle ramifié comportant une ou plusieurs fonctions éther, un groupe tétrahydrofurfuryle ou éther, un groupe tétrahydrofurfuryle ou du type dioxaspiro ou dialkoxy pipéridino.
Bellande Emmanuel
Comazzi Veronique
Laine Jacques
Pasqualini Roberto
Cis Bio International
Goudreau Gage Dubuc
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