A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/352 (2006.01) A61K 31/35 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2370553
Compositions comprising formononetin and/or one or more isoflavones selected from biochanin, genistein and daidzein, in a therapeutically effective ratio of formononetin to said isoflavones of 15:1 to 2:1, optionally in association with one or more carriers, excipients, auxiliaries and/or diluents are described. Also described are methods of treatment involving such compositions including the prevention and/or treatment of cardiovascular disease, the beneficial alteration of blood lipoprotein levels, or a reduction in the risk of vascular disease, or a reduction in the risk of coronary heart disease, or a reduction in the risk of arteriosclerosis, or in the beneficial alteration or maintenance of bone density such as in the prevention or treatment of osteoporosis, and/or in the prevention and/or treatment of bone fracture.
L'invention concerne des compositions contenant de la formononétine et/ou une ou plusieurs isoflavones choisies dans le groupe constitué par biochanine, génistéine et daïdzéine, dans un rapport thérapeutiquement efficace de la formononétine aux isoflavones variant entre 15:1 et 2:1, éventuellement associées à un ou plusieurs supports, excipients et/ou diluants. L'invention concerne également des méthodes de traitement comprenant ces compositions, telles que la prévention et/ou le traitement d'une maladie cardiovasculaire, l'altération bénéfique des taux de lipoprotéines dans le sang, la réduction du risque d'affection vasculaire, de coronaropathie ou d'artériosclérose, l'altération bénéfique ou l'entretien de la densité osseuse, notamment dans la prévention ou le traitement de l'ostéoporose, et/ou la prévention et/ou le traitement d'une fracture osseuse.
Husband Alan James
Kelly Graham Edmund
Gowling Lafleur Henderson Llp
Novogen Research Pty Ltd.
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