Cardiovascular composition containing nifedipine

A - Human Necessities – 61 – K

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A61K 31/455 (2006.01) A61K 9/14 (2006.01) A61K 31/44 (2006.01) C07D 211/90 (2006.01)

Patent

CA 1228550

Two-phase formulation ABSTRACT In the treatment of cardiovascular and coronary disorders by administering to a patient suffering there- from a solid preparation comprising nifedipine, the improvement which comprises administering such nife- dipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapid- ly enters the blood stream in a relatively high concen- tration which is maintained for a relatively long time.

454635

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