C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07B 59/00 (2006.01) C12Q 1/00 (2006.01) C40B 30/04 (2006.01) G01N 33/50 (2006.01) G01N 33/60 (2006.01) G01N 33/68 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 70/00 (2006.01)
Patent
CA 2450581
The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.
La présente invention concerne des méthodes d'analyse et des nécessaires pour le criblage de composés d'essai relativement à leur aptitude à induire une cardiotoxicité chez un sujet. Ces méthodes d'analyse et ces nécessaires reposent sur la constatation que l'interaction de l'astémizole avec le canal potassique HERG peut être exploitée pour prévoir la cardiotoxicité de composés dans le cadre du développement de nouveaux médicaments et d'autres agents.
Heylen Godelieve Irma Christine Maria
Janssen Cornelus Gerardus Maria
Jurzak Mirek Roman
Van Assouw Henricus Petrus Martinus Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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