Carrier

Details Carrier Carrier

A - Human Necessities

61

K

A61K 47/22 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 31/355 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 49/18 (2006.01) A61P 27/00 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2756181

A pharmaceutical composition is provided comprising a vitamin E derivative, an anionic phopholipid-binding protein, an anionic phospholipid and a sterol. Also provided is a method for preparing a composition for delivering a cargo to a subject comprising a) forming liposomes from a vitamin E derivative, an anionic phospholipid-binding protein such as annexin, an anionic phospholipid such as phosphatidylserine and a sterol; and b) encapsulating the cargo in the liposomal composition.

La présente invention concerne une composition pharmaceutique comprenant un dérivé de vitamine E, une protéine de liaison à un phospholipide anionique, un phospholipide anionique et un stérol. L'invention porte en outre sur un procédé de préparation d'une composition destinée à fournir un chargement à un sujet, comprenant les étapes suivantes : a) formation de liposomes à partir d'un dérivé de vitamine E, d'une protéine de liaison à un phospholipide anionique tel que l'annexine, d'un phospholipide anionique tel que la phosphatidylsérine et d'un stérol ; et b) enrobage du chargement dans la composition liposomale.

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