Carrier composition for nucleic acid transport

Details Carrier composition for nucleic acid transport Carrier composition for nucleic acid transport

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61K 47/18 (2006.01) A61K 47/28 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2624840

Disclosed is a carrier composition for nucleic acid transport, which can protect a nucleic acid (e.g., siRNA) from decomposition and transport the nucleic acid into a cell with good efficiency when the carrier composition is administered to an animal cell or a living organism and has low toxicity. Also disclosed is a nucleic acid transport composition which comprises the carrier composition and a nucleic acid. The carrier composition can be prepared by mixing (A) a cationic lipid having a steroid nucleus with (B) a cationic lipid of a quaternary ammonium salt type. The nucleic acid transport composition can be prepared by mixing the carrier composition with a nucleic acid.

La présente invention concerne une composition vectrice pour le transport d'un acide nucléique, la composition vectrice présentant une faible toxicité et étant capable de protéger de la décomposition l'acide nucléique (par exemple un ARN interférant court - siRNA) et de le transporter dans une cellule avec une bonne efficacité lorsque la composition vectrice est administrée à une cellule animale ou à un organisme vivant. L'invention concerne également une composition de transport d'un acide nucléique qui comprend la composition vectrice et un acide nucléique. La composition vectrice peut être préparée en mélangeant (A) un lipide cationique comportant un noyau stéroïde avec (B) un lipide cationique de type sel d'ammonium quaternaire. La composition de transport d'acide nucléique peut être préparée en mélangeant la composition vectrice avec un acide nucléique.

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