Carrier conjugates of gnrh-peptides

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) C07K 7/23 (2006.01)

Patent

CA 2575997

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus like particle (VLP) and at least one GnRH peptide or fragment or variant thereof linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of GnRH-related diseases and conditions and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self- specific immune responses within the indicated context.

L'invention concerne les domaines de la biologie moléculaire, de la virologie, de l'immunologie et de la médecine. On décrit une composition qui renferme une particule pseudovirale et au moins un peptide GnRH ou bien un fragment ou un variant correspondant lié à ladite particule. On décrit aussi un procédé de production de ce type de composition. Les compositions considérées sont utiles pour la production de vaccins utilisés dans le traitement des maladies et affections liées à la GnRH et dans l'induction efficace des réponse immunes, en particulier des réponses d'anticorps. Enfin, ces compositions sont particulièrement utiles pour induire efficacement des réponses immunes à spécificité autonome dans le contexte considéré.

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