Cartilage and bone repair composition

Details Cartilage and bone repair composition Cartilage and bone repair composition

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) C12N 5/0775 (2010.01) A61K 38/18 (2006.01) A61K 38/39 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2567314

The invention relates to a cartilage and bone repair composition comprising a group of human mesenchymal stem cells that are differentiated to the chondro- osteogenic lineage, by means of the amplification thereof with human serum and a transforming growth factor-beta 1 with a molecular domain for binding to collagen I (TGF-~1-DUC) obtained in eukaryotic expression systems, and a biocompatible material which is absorbed by the cells thus treated. The inventive composition can be employed using implants in the area to be repaired or it can be employed directly by injecting the cells in suspension either at the site of the injury or into the systemic circulation for the widespread distribution thereof.

L'invention concerne une composition de réparation osseuse et cartilagineuse comprenant un ensemble de cellules mères mésenchymateuses humaines différenciées vers la lignée chondro-ostéogénique, par amplification avec du sérum humain et un facteur de croissance de transformation bêta 1 avec un domaine moléculaire de liaison au collagène I (TGF-ß1-DUC) obtenu dans des systèmes d'expression eucaryotiques, et un matériau biocompatible d'absorption des cellules ainsi traitées. Cette composition peut être utilisée à l'aide d'implants dans la zone à traiter ou directement par injection des cellules en suspension, sur le site de la lésion, ou y compris dans la circulation systémique pour sa distribution généralisée.

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