G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2682503
The inventions relates method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2(CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2Cl) or fragments thereof. The invention also regards antibodies immunoreactive with the protein or fragments thereof and a kit comprising such an antibody and instructions for use in conducting an assay.
L'invention concerne des procédés permettant de différencier l'ostéoarthrite de l'arthrite rhumatoïde et d'états non pathologiques dans un échantillon, qui consiste à mesurer dans cet échantillon la concentration de protéines 2(CILP-2) de couche intermédiaire cartilagineuse dans des liquides corporels et plus spécifiquement, à mesurer dans l'échantillon la concentration de la partie N-terminal de CILP-2 (2Cl) ou de fragments de celle-ci. L'invention concerne aussi des anticorps immunoréactifs avec cette protéine ou des fragments de celle-ci et un kit comprenant cet anticorps ainsi que des instructions d'utilisation permettant de conduire ce dosage.
Heinegard Dick
Lorenzo Pilar
Saxne Tore
Anamar Medical Ab
Smart & Biggar
LandOfFree
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