Cartilage or bone matrix as a nucleic acid delivery vehicle

Details Cartilage or bone matrix as a nucleic acid delivery vehicle Cartilage or bone matrix as a nucleic acid delivery vehicle

A - Human Necessities

61

L

A61L 27/22 (2006.01) A61F 2/28 (2006.01) A61F 2/30 (2006.01) A61F 2/44 (2006.01) A61K 48/00 (2006.01) A61L 27/36 (2006.01) A61L 27/54 (2006.01) C07K 14/475 (2006.01) C07K 14/51 (2006.01) A61F 2/00 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2379663

The present invention relates to tissues, including but not limited to bone and cartilage implants, as carrier matrices for delivery of biologically active nucleic acids to sites where such tissues are to be implanted. Upon implantation, the nucleic acids associated with the implants are taken up by cells within the implant site and are expressed, to produce growth factors, regenerative factors and the like encoded by the nucleic acids. In this manner, for example, where the nucleic acid encodes bone morphogenetic protein or the like, the rate of bone induction, conduction of healing and the rate of cartilage formation or repair is enhanced, without the attendant need to manufacture, purify, isolate and deliver protein or peptide growth factors.

La présente invention porte sur des tissus, notamment mais pas exclusivement, sur des implants osseux et de cartilage utilisés comme matrices de support pour administrer des acides nucléiques biologiquement actifs sur des sites où ces tissus doivent être implantés. Lors de l'implantation, les acides nucléiques associés aux implants sont absorbés par des cellules dans le site d'implantation et sont exprimés de façon à produire des facteurs de croissance, des facteurs régénérateurs et analogues codés par les acides nucléiques. De cette manière, par exemple, l'acide nucléique code une protéine morphogénétique osseuse ou analogue, la vitesse d'induction osseuse, de conduction ou de cicatrisation, et la vitesse de formation du cartilage ou réparation étant ainsi améliorées sans qu'il y ait besoin de fabriquer, purifier, isoler et administrer des facteurs de croissance de protéine ou de peptide.

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