Cartilage regeneration using chondrocyte and tgf-.beta.

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) C12N 5/077 (2010.01) A61K 35/32 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2479042

The present application is directed to a method of treating osteoarthritis, which includes obtaining a member of a transforming growth factor superfamily of proteins; obtaining a population of cultured connective tissue cells that may contain vector encoding a gene, or a population of cultured connective tissue cells that do not contain any vector encoding a gene; and then transferring the protein and the connective tissue cells into an arthritic joint space of a mammalian host, such that the activity of the combination within the joint space results in regenerating connective tissue.

L'invention porte sur un procédé de traitement de l'ostéoarthtose consistant: à obtenir une protéine membre de la superfamille des facteurs de croissance transformants; à obtenir une population de cellules de tissus conjonctifs de culture pouvant contenir un vecteur codant pour un gène ou une population de cellules de tissus conjonctifs de culture ne contenant aucun vecteur codant pour un gène; puis à transférer les protéines et les tissus conjonctifs dans l'espace d'une articulation arthritique de mammifère pour que l'activité de la combinaison y produise une regénération des tissus conjonctifs.

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