Cartilage repair methods

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/14 (2006.01) A61K 31/765 (2006.01)

Patent

CA 2631520

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

Procédés de réparation de défauts dans du cartilage hyalin. Les procédés comportent une combinaison d'introduction de cellules souches osseuses mésenchymateuses autologues dans une articulation et d'application à l'articulation d'une membrane comportant un polyester enchevêtré avec un polysaccharide. Dans certains aspects, les cellules souches osseuses mésenchymateuses sont des cellules souches mésenchymateuses issues de l'os sous-jacent à l'articulation. Dans ces aspects, le contact entre l'articulation et les cellules souches mésenchymateuses peut être réalisé en pratiquant des orifices dans l'os à l'aide de techniques chirurgicales standard telles que la microfracture, l'abrasion ou le perçage. Le cartilage qui se forme en réponse à l'application de ces procédés est du cartilage hyalin plutôt que du fibrocartilage.

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