Cartillage matrix protein and methods for use

Details Cartillage matrix protein and methods for use Cartillage matrix protein and methods for use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/36 (2006.01) A61K 38/39 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61L 27/00 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61L 25/00 (1990.01)

Patent

CA 2117780

2117780 9321226 PCTABS00027 In general, the invention features a substantially pure polypeptide which is a fragment or analog of cartilage matrix protein, the polypeptide being capable of binding collagen. In various preferred embodiments the polypeptide includes CMP-1 or CMP-2; the polypeptide is all or part of CMP-1; the polypeptide is all or part of CMP-2; and the polypeptide is all or part of CMP-1 and CMP-2. In a related aspect, the invention features a method for forming collagen fibrils. The method includes contacting cartilage matrix protein with collagen. In another related aspect, the invention features a method for delivering a compound to collagenous tissue, the method includes administering to a patient the compound linked to a polypeptide which includes CMP-1 or CMP-2. In another aspect, the invention features molecular conjugate which includes a collagen-binding fragment of cartilage matrix protein and an imaging or therapeutic agent.

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