A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/403 (2006.01) A61K 31/454 (2006.01)
Patent
CA 2326840
The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70 % after 30 minutes, prepared in accordance with the process of the invention.
L'invention se rapporte à un procédé de préparation de compositions pharmaceutiques à dissolution rapide à partir de substances actives difficilement solubles, selon lequel on prépare une suspension aqueuse à partir de la substance active et d'un ou de plusieurs adjuvants hydrosolubles puis on traite la suspension aqueuse (après en avoir évacué l'eau) par des procédés connus afin de former des préparations pharmaceutiques solides. L'invention se rapporte également à des préparations pharmaceutiques à dissolution rapide, obtenues à partir de substances actives possédant un taux de dissolution d'au moins 70 % en trente minutes. Ces préparations sont fabriquées selon le procédé de l'invention.
Gabel Rolf-Dieter
Preis Walter
Wirl Alexander
Gowling Lafleur Henderson Llp
Roche Diagnostics Gmbh
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