Carvedilol hydobromide

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2492084

The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy-3-[[2- (o~methoxyphenoxy)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.

La présente invention se rapporte à un sel de carvédilol, à des compositions correspondantes contenant ce sel de carvédilol ou à des solvates correspondant de celui-ci, et/ou à des procédés d'utilisation du ou des composés ci-dessus mentionnés dans le traitement de certains états pathologiques chez des mammifères, notamment chez l'homme. La présente invention se rapporte en outre à une nouvelle forme cristalline d'hydrobromure de carvédilol, qui est le sel hydrobromure du 1-(carbazol-4-yloxy-3-[[2-(o-méthoxyphénoxy)éthyl]amino]-2-propanol, et/ou à des solvates de carvédilol de ce sel, à des compositions contenant des sels ou solvates d'hydrobromure de carvédilol, ainsi qu'à des procédés d'utilisation du ou des composés mentionnés ci-dessus pour traiter l'hypertension, l'insuffisance cardiaque globale et l'angine de poitrine, etc..

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