Casoase 3 inhibitors

Details Casoase 3 inhibitors Casoase 3 inhibitors

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) A61P 7/06 (2006.01) A61P 9/02 (2006.01) A61P 9/10 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2439193

It is intended to develop drugs capable of directly or indirectly inhibiting the activation of caspase. More specifically speaking, caspase 3 inhibitors containing proteins having an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:31 or salts thereof. These proteins, peptide fragments thereof or salts thereof are useful as drugs such as preventives and/or remedies for AIDS, fulminant hepatitis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, pigmentary retinopathy, cerebellar denaturation, myelodysplastic syndrome, aplastic anemia, sideroblastic anemia, myocardial ischemia, conduction failure, chronic heart failure, graft-versus-host disease, congenital or acquired enzymatic failure, etc.

L'invention concerne des médicaments capables d'inhiber directement ou indirectement l'activation de caspase. Elle concerne plus spécifiquement des inhibiteurs de caspase 3 contenant des protéines, ou des sels de ces protéines, dont la séquence en acides aminés est la même ou sensiblement la même que les séquences d'acides aminés représentées dans les SEQ ID N·1, SEQ ID N·2, ou SEQ ID N·31. Ces protéines, ou des fragments peptidiques ou des sels de ces protéines sont utiles comme médicaments, pour prévenir ou traiter des maladies notamment le sida, l'hépatite fulminante, la maladie d'Alzheimer, la maladie de Parkinson, la sclérose latérale amyotrophique, la rétinopathie pigmentaire, la dénaturation cérébelleuse, le syndrome myélodysplasique, l'anémie aplasique, l'anémie sidéroblastique, l'ischémie du myocarde, l'insuffisance de transmission, l'insuffisance cardiaque chronique, la maladie de greffon contre l'hôte, et l'insuffisance enzymatique acquise ou congénitale.

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