Caspase-14, an apoptotic protease, nucleic acids encoding...

Details Caspase-14, an apoptotic protease, nucleic acids encoding... Caspase-14, an apoptotic protease, nucleic acids encoding...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 16/40 (2006.01) C12N 5/16 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301779

The invention relates to an isolated nucleic acid molecule encoding a caspase- 14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that contains the vector. The invention also relates to an isolated gene encoding caspase-14, as well as functional fragments thereof. The gene or nucleic acid molecule can include single or double stranded nucleic acids corresponding to coding or non-coding strands of the caspase-14 nucleotide sequence. Isolated caspase-14 polypeptides or functional fragments thereof are also provided, as are antibodies that specifically bind thereto. In addition, the invention relates to methods of identifying compounds that modulate caspase-14 activity.

L'invention concerne une molécule d'acides nucléiques isolée codant un polypeptide caspase-14 ou un fragment fonctionnel de celui-ci, un vecteur contenant ladite molécule et une cellule hôte renfermant ce vecteur. L'invention concerne également un gène isolé codant le type caspase-14 et des fragments fonctionnels de celui-ci. Dans le gène ou la molécule d'acides nucléiques, on peut trouver des acides nucléiques à un ou deux brins correspondant aux brins qui codent ou non la séquence nucléotidique caspase-14. L'invention concerne également des polypeptides caspase-14 isolés ou des fragments fonctionnels de ces polypeptides, ainsi que des anticorps se liant spécifiquement à eux. L'invention concerne en outre des procédés permettant d'identifier des composés qui modulent l'activité du polypeptide caspase-14.

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