Caspase-14, an apoptotic protease, nucleic acids encoding...

Details Caspase-14, an apoptotic protease, nucleic acids encoding... Caspase-14, an apoptotic protease, nucleic acids encoding...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2350167

The invention relates to an isolated nucleic acid molecule encoding a caspase- 14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that contains the vector. The invention also relates to an isolated gene encoding caspase-14, as well as functional fragments thereof. The gene or nucleic acid molecule can include single or double stranded nucleic acids corresponding to coding or non-coding strands of the caspase-14 nucleotide sequence. Isolated caspase-14 polypeptides or functional fragments thereof are also provided, as are antibodies that specifically bind thereto. In addition, the invention relates to methods of identifying compounds that modulate caspase-14 activity.

L'invention concerne une molécule d'acide nucléique isolée codant pour un polypeptide de caspase-14 ou un fragment fonctionnel de ce dernier, un vecteur contenant cette molécule d'acide nucléique et une cellule hôte contenant ce vecteur. L'invention concerne également un gène isolé codant pour la caspase-14, ainsi que des fragments fonctionnels de ce gène. Ce gène ou cette molécule d'acide nucléique peuvent comprendre des acides nucléiques à simple ou à double brin correspondant à des brins codants ou non codants de la séquence nucléotidique de la caspase-14. L'invention concerne en outre des polypeptides de caspase-14 isolés ou des fragments fonctionnels de ces derniers, ainsi que des anticorps qui se lient spécifiquement à ces derniers. Enfin, L'invention concerne des procédés permettant d'identifier des composés modulant l'activité caspase-14.

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