Caspase inhibitor prodrugs

Details Caspase inhibitor prodrugs Caspase inhibitor prodrugs

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/429 (2006.01)

Patent

CA 2616337

This invention relates to prodrugs of caspase inhibitors comprising of a furo [3, 2-d] oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. This invention also relates to the processes for preparing these prodrugs of caspase inhibitors. This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.

L'invention concerne des promédicaments d'inhibiteurs de la caspase comprenant un fraction furo [3, 2-d] oxazolin-5-one qui, dans des conditions spécifiques, peuvent se convertir en composés bioactifs, notamment des inhibiteurs de la caspase. L'invention concerne également les procédés de préparation de promédicaments d'inhibiteurs de la caspase. L'invention concerne enfin les compositions pharmaceutiques comprenant lesdits promédicaments et leur utilisation dans le traitement de maladies associées aux états inflammatoires ou dégénératifs.

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