Caspase inhibitors and the use thereof

Details Caspase inhibitors and the use thereof Caspase inhibitors and the use thereof

C - Chemistry, Metallurgy

07

C

C07C 229/00 (2006.01) C07C 61/08 (2006.01) C07C 205/00 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07C 311/19 (2006.01) C07D 295/205 (2006.01) C07D 311/16 (2006.01) C07D 311/66 (2006.01)

Patent

CA 2369619

The present invention is directed to novel dipeptide thereof, represented by general formula (I); where R1-R3 X and Y are defined herein. The present invention also relates to the discovery that Compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues of entire organs occurs.

L'invention concerne un nouveau dipeptide de formule générale (I), dans laquelle R1-R3, X et Y sont tels que définis ici. L'invention concerne également une découverte fondée sur le rôle que jouent les composés de la formule I en tant qu'inhibiteurs efficaces des caspases et de la mort cellulaire apopétotique. Aussi, les inhibiteurs précités sont-ils en mesure de retarder ou de bloquer la mort cellulaire dans des pathologies cliniques variées présentant une perte de cellules, de tissus ou d'organes entiers.

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