Caspase inhibitors and uses thereof

Details Caspase inhibitors and uses thereof Caspase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 239/90 (2006.01) A61K 31/395 (2006.01) C07D 209/44 (2006.01) C07D 217/24 (2006.01) C07D 239/36 (2006.01) C07D 239/80 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07K 5/06 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2733434

This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula (I): See Formula (I) where R1, R2, and R3 are as described herein, Ring A contains zero to two double bonds, each X is independently selected from nitrogen or carbon, at least on X is Ring A is a nitrogen, Ring A is optionally substituted as described, and may be fused to a saturated or unsaturated five to seven membered ring containing zero to three heteroatoms, and provided that when X3 is a carbon, a substituent on X3 is attached by an atom other than nitorgen.

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