Cassette regulating the expression of a heterologous nucleic...

Details Cassette regulating the expression of a heterologous nucleic... Cassette regulating the expression of a heterologous nucleic...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2366125

The invention relates to a cassette regulating the expression of a heterologous nucleic acid in a eucaryotic cell, especially a muscle cell, a recombinant expression vector containing said regulating cassette and a recombinant cell host or transgenic animal containing said regulating cassette or recombinant vector. The invention also relates to a composition, especially a pharmaceutical composition, comprising said cassette regulating a heterologous nucleic acid in a muscle cell or the recombinant vector, in addition to the use of said regulating cassette or recombinant vector in the production of a medicament.

La présente invention concerne une cassette de régulation de l'expression d'un acide nucléique hétérologue dans une cellule eucaryote, en particulier musculaire, un vecteur d'expression recombinant comprenant une telle cassette de régulation ainsi qu'un hôte cellulaire recombinant ou un animal transgénique contenant ladite cassette de régulation ou ledit vecteur recombinant. L'invention concerne aussi une composition, notamment une composition pharmaceutique, comprenant la cassette de régulation d'un acide nucléique hétérologue dans une cellule musculaire ou le vecteur recombinant ainsi que l'utilisation de la cassette de régulation ou du vecteur recombinant pour la fabrication d'un médicament.

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