Cat allergen fusion proteins and uses thereof

Details Cat allergen fusion proteins and uses thereof Cat allergen fusion proteins and uses thereof

A - Human Necessities

61

K

A61K 39/35 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2599218

The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

L'invention concerne les domaines de la médecine, de la santé publique, de l'immunologie, de la biologie et de la virologie moléculaires. L'invention concerne des compositions comprenant une particule de type viral (VLP) ou une particule virale et au moins un antigène, en particulier au moins un antigène du chat, et plus particulièrement au moins un antigène du chat qui est un allergène humain. Dans certains modes de réalisation, l'antigène est un antigène Fel d1 ou un fragment de celui-ci, lié par covalence au VLP. L'invention concerne également des procédés de production des compositions. Lesdites compositions de l'invention induisent des réponses immunitaires, en particulier des réponses anticorps, chez des mammifères, en particulier des humains. Les compositions et les procédés de l'invention s'avèrent utiles pour la production de vaccins, en particulier pour le traitement et/ou la prévention d'allergies aux phanères du chat et à d'autres antigènes et allergènes du chat.

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