C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2022959
The present invention is directed to: a gene fragment which includes a DNA sequence coding for an amino acid sequence of a constant region of a feline immunoglobulin .lambda. chain; a gene fragment which includes a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglubulin K chain; a gene fragment which includes a DNA sequence coding for the constant region of feline immunoglubulin .gamma. chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which includes a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein the recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene. These products and processes can be used for the diagnosis, treatment and prevention of feline diseases.
Eda Yasuyuki
Kimachi Kazuhiko
Maeda Hiroaki
Ono Yoichi
Tokiyoshi Sachio
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
LandOfFree
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