B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 31/02 (2006.01) B01J 31/18 (2006.01) C07C 253/00 (2006.01) C07C 255/38 (2006.01)
Patent
CA 2487295
A vanadium catalyst and a process for cyanating an aldehyde are provided. The vanadium catalyst comprises a Vanadium(V) salen complex. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si- CN bond or a C-(C=O)-CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral vanadium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.
L'invention concerne un catalyseur au vanadium et un procédé de cyanation d'un aldéhyde. Ce catalyseur de vanadium comprend un complexe de salen de vanadium (V). Ce procédé consiste à faire réagir de l'aldéhyde avec: i) une source de cyanide qui ne comprend pas de liaison Si-CN ou un fragment C-(C=O)-CN; et ii) un substrat sensible à l'attaque nucléophile qui ne comprend pas d'halogène de groupe partant; en présence d'un catalyseur de vanadium chiral. La source de cyanide est de préférence un cyanide métallique alcalin et le substrat sensible à l'attaque nucléophile et qui ne comprend pas de groupe partant halogène est un anhydride carboxylique.
Belokon Yuri
North Michael
King's College London
Nesmeyanov Institute Of Organoelement Compounds
Smart & Biggar
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