Catalytic and reactive polypeptides and methods for their...

Details Catalytic and reactive polypeptides and methods for their... Catalytic and reactive polypeptides and methods for their...

C - Chemistry, Metallurgy

12

P

530/17, 195/86,

C12P 21/00 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 9/00 (2006.01) C12N 9/86 (2006.01) C12N 15/00 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2003273

81 2307U-255-1 CATALYTIC AND REACTIVE POLYPEPTIDES AND METHODS FOR THEIR PREPARATION AND USE Abstract of the Disclosure Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like.

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