Catalytic antibodies which hydrolyze primary amides and...

Details Catalytic antibodies which hydrolyze primary amides and... Catalytic antibodies which hydrolyze primary amides and...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07C 233/31 (2006.01) C07D 207/452 (2006.01) C07F 9/30 (2006.01) C07F 9/32 (2006.01) C07F 9/40 (2006.01) C07F 9/48 (2006.01) C07F 9/553 (2006.01) C07F 9/572 (2006.01) C07K 4/00 (2006.01) C07K 7/08 (2006.01) C07K 14/585 (2006.01) C07K 14/595 (2006.01) C07K 16/44 (2006.01) C12N 9/00 (2006.01) C12N 9/80 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2161114

Described and claimed are compounds of formula (I) wherein Y is a polypeptide, R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl, alkene, or alkyne group, R2 is a side chain of a naturally occurring amino acid, and X is (a), (b), (c). Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.

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