Catalytic domains of .beta./1,4)-galactosyltransferase i...

Details Catalytic domains of .beta./1,4)-galactosyltransferase i... Catalytic domains of .beta./1,4)-galactosyltransferase i...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/14 (2006.01) A61K 39/00 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12P 19/00 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2510550

Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the immunogenicity of an antigen; and polypeptide stem regions that can be used to promote in vitro folding of polypeptides, such as the catalytic domain from a galactosyltransferase.

L'invention concerne des méthodes et des compositions qui peuvent être utilisés pour synthétiser des oligosaccharides ; des mutants de galactosyltransférases présentant une spécificité modifiée de donneur et d'accepteur ; des méthodes permettant d'accroître l'immunogénicité d'un antigène ; et des régions souches de polypeptides qui peuvent servir à faciliter le pliage in vitro de polypeptides, telles que le domaine catalytique d'une galactosyltransférase.

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