Catalytic domains of the human hepatocyte growth factor...

Details Catalytic domains of the human hepatocyte growth factor... Catalytic domains of the human hepatocyte growth factor...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07D 513/04 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) G06F 17/00 (2006.01)

Patent

CA 2378494

The identification, isolation, purification, and characterization of the catalytic domain of the human hepatocyte growth factor receptor kinase (hHGFR) are described. A crystal structure of the hHGFR kinase domain is reported herein. This structure provides a three- dimensional description of the binding site of the hHGFR for structure-based design of small molecule inhibitors thereof as therapeutic agents. The kinase domain of human HGFR and its associated crystal structure is described for use in the discovery, identification and characeterization of modulators of human HGFR.

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