Catalytic monoclonal antibodies for the in vivo...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/00 (2006.01) C07J 51/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2299623

Catalytic monoclonal antibodies (abzymes) for the in vivo transformation of corticosteroid prodrugs ae herein disclosed. These abzymes are advantageously used in emergency therapy of acute adrenal insufficiency allowing a prompt pharmacological action of the corticosteroid. Haptens against which the abzymes are generated are also disclosed.

L'invention concerne des anticorps monoclonaux catalytiques (abzymes) servant à la transformation in vivo de bioprécurseurs de corticostéroïdes. Ces abzymes sont utilisées avec avantage dans le traitement d'urgence de l'insuffisance surrénale aiguë car ils permettent une action pharmacologique rapide des corticostéroïdes. L'invention concerne également des haptènes utilisés pour produire les abzymes.

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