Catalytic monoclonal antibodies with protease activity for...

Details Catalytic monoclonal antibodies with protease activity for... Catalytic monoclonal antibodies with protease activity for...

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2299442

Catalytic monoclonal antibodies (abzymes) with selective protease activity in the pathologies characterized by the presence of plaques and fibrillar aggregates with protein component; methods for the preparation thereof and the use thereof as medicaments in the treatment of pathologies such as Alzheimer's disease, amyloidosis, atherosclerosis, prions diseases.

L'invention concerne des anticorps monoclonaux catalytiques (abzymes) présentant une activité protéase sélective dans les pathologies caractérisées par la présence de plaques et d'agrégats fibrillaires comprenant une fraction protéinique. L'invention concerne également la préparation de ces anticorps et l'utilisation de ces derniers en tant que médicaments dans le traitement de pathologies telles que la maladie d'Alzheimer, l'amylose, l'athérosclérose et les maladies à prions.

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