Catechol diether compounds as inhibitors of tnf release

Details Catechol diether compounds as inhibitors of tnf release Catechol diether compounds as inhibitors of tnf release

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/085 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/21 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/425 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2158632

This invention relates to catechol diether compounds which are inhibitors of tumor necrosis factor (TNF). The catechol diether compounds are useful as inhibitors of TNF per se and in the treatment or alleviation of inflammatory conditions or disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tuberculosis, graft versus host disease and cachexia associated with AIDS or cancer. This invention also relates to pharmaceutical compositions useful therefor.

L'invention a trait aux composés de catéchol diéther qui inhibent le facteur de nécrose des tumeurs (TNF). Ces composés sont utiles comme inhibiteurs du TNF en soi et dans le traitement ou l'atténuation de l'inflammation ou de la maladie, y compris sans s'y limiter, de la polyarthrite rhumatoïde, de l'arthrose, de l'asthme, de la bronchite, des troubles ventilatoires chroniques obstructifs, du psoriasis, de la rhinite allergique, de la dermatite et de la maladie intestinale inflammatoire, de la septicémie, du choc septique, de la tuberculose, de la maladie du greffon contre l'hôte et de la cachexie associée au SIDA et au cancer. Cette invention concerne aussi les compositions pharmaceutiques utiles à ces fins.

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