Catecholamine derivatives

Details Catecholamine derivatives Catecholamine derivatives

C - Chemistry, Metallurgy

07

C

167/267, 167/276

C07C 215/56 (2006.01) A61K 31/135 (2006.01) C07C 215/54 (2006.01) C07C 311/08 (2006.01)

Patent

CA 1294289

Abstract Compounds There are described compounds of formula I, Image in which one of R30 and R40 represents a group Ra, Image Ra and the other of R30 and R40 represents hydrogen or halogen, R50 and R60, which may be the same or different, each independently represent hydrogen or alkyl C 1 to C6; in addition R60 may represent a group Rb, Rb Image wherein X represents a C2 to C8 alkylene chain optionally interrupted by a double bond or by S(0)n, wherein n is 0, 1 or 2, Z represents a C 1 to C3 alkylene chain, each of X and Z being optionally substituted by OH or one or more alkyl C 1 to C6, R70 represents hydrogen, alkyl C 1 to C6 or (CH2)qR11, R10 and R11 independently represent phenyl substituted by one or more substituents R23, which may be the same or different; or R10 represents a saturated carbocyclic group, R15 represents hydrogen, alkyl C 1 to C6, or together with R23 forms a (CH2)p chain, wherein p represents 0, 1 or 2, R20, R21, R22 and R23 independently represent hydrogen, alkyl C 1 to C6, NHR25, SH, NO2, halogen, CF3, SO2R26, CH20H or O~, wherein R25 represents hydrogen, alkyl C 1 to C6 or alkanoyl C 1 to C6 and R26 represents alkyl C 1 to C6 or NH2 1 represents 2, 3 or 4, q represents an integer from 1 to 6 inclusive, provided that when R40, R50 and R70 each represent hydrogen and R60 represents Rb, then Ra represents 2(3-hydroxyphenyl)ethyl, R15 represents hydrogen and either a) X represents (CH2)p, in which p is 3, 5, 7 or 8 or b) at least one of X and Z is substituted by either OH or one or more alkyl C 1 to C6, and pharmaceutically acceptable salts and solvates thereof. There are also described processes for the preparation of the compounds of formula I and pharmaceutical compositions containing them. The compounds of the invention may be used in the treatment or prophylaxis of renal failure or cardiovascular disorders. 2038L(ir)/ac

567118

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