C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/231, 167/273
C07C 215/52 (2006.01) C07C 323/25 (2006.01) C07C 323/29 (2006.01) C07D 213/38 (2006.01) C07D 213/53 (2006.01)
Patent
CA 1275103
ABSTRACT There are described compounds of formula I, Image I in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O)n, wherein n is 0, 1 or 2: Y represents o or NH, 1 and m each independently represent 2, 3 or 4, R10 represents phenyl substituted by one or more substituents R23, which may be the same or different; or R10 represents pyridyl, a saturated carbocyclic group, alkyl C 1 to 6 or hydrogen, R15 represents hydrogen or together with R23 forms a (CH2)p chain, wherein p represents 0, 1 or 2; R20, R21, R22 and R23, which may be the same or different, independently represent hydrogen, alkyl C 1 to 6, NHR25, SH, NO2, halogen, CF3, SO2R30, CH2OH or OH, wherein R25 represents hydrogen, alkyl C 1 to 6, alkanoyl C 1 to 6 or SO2 alkyl C 1 to 6, and R30 represents alkyl C 1 to 6 or NH2, provided that when X represents an uninterrupted C4 alkylene chain, Y represents NH, m represents 2, 1 represents 2, R10 represents phenyl, R15 represents hydrogen, and R21, R22 and R23 represent hydrogen, then R20 does not represent hydrogen or 4-OH, and pharmaceutically acceptable salts and solvates thereof. There are also described processes for the preparation of the compounds of formula I and pharmaceutical compositions containing them. The compounds of the invention may be used in the treatment or prophylaxis of renal failure or cardiovascular disorders.
523392
Dixon John
Ince Francis
Springthorpe Brian
Dixon John
Fisons Plc
Ince Francis
Ridout & Maybee Llp
Springthorpe Brian
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