Cathepsin cysteine protease inhibitors

Details Cathepsin cysteine protease inhibitors Cathepsin cysteine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/341 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4433 (2006.01) A61K 31/445 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) A61P 19/08 (2006.01) C07D 207/24 (2006.01) C07D 211/74 (2006.01) C07D 213/65 (2006.01) C07D 309/30 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2552726

The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR1R2, O, S, -SO2, C=0 or NR9; Z is CR1R2, O, S, -SO2, C=O or NR9 and each G is independently a CR1CR2. Said compounds are cathepsin cysteine protease inhibitors, including but not limited to, inhibitors of cathepsin K, L, S and B and to pharmaceutical compositions thereof. These compounds are useful for treating and preventing cathepsin dependent conditions in which inhibition of bone resorption is indicated, such as osteoporosis.

La présente invention concerne une nouvelle classe de composés, essentiellement des dérivés de leucinamide-amino-carboxylate représentés par la formule (I) dans laquelle Y est CR?1¿R?2¿, O, S, -SO¿2?, C=0 ou NR?9¿; Z est CR?1¿R?2¿, O, S, -SO¿2?, C=O ou NR?9¿ et chaque G est indépendamment un CR?1¿CR?2¿. Lesdits composés sont des inhibiteurs des cystéines protéases de type cathepsine, y compris, entre autres, des inhibiteurs de la cathepsine K, L, S et B. L'invention concerne également des compositions pharmaceutiques desdits composés. Ces composés sont utilisés dans le traitement et la prévention d'états dépendant de la cathepsine dans lesquels est indiquée l'inhibition de la résorption osseuse, par exemple l'ostéoporose.

Affiliated with

Also associated with

Rating

Cathepsin cysteine protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cathepsin cysteine protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cathepsin cysteine protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2036315