Cathepsin cysteine protease inhibitors

Details Cathepsin cysteine protease inhibitors Cathepsin cysteine protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 255/46 (2006.01) A61K 31/426 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07C 255/44 (2006.01) C07C 255/45 (2006.01) C07D 277/02 (2006.01) C07D 277/20 (2006.01) C07D 277/30 (2006.01)

Patent

CA 2535359

This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of G, E, E, n, R1, R2, R3 et R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

La présente invention concerne une nouvelle classe de composés représentés par la formule ci-dessous, les significations de G, E, E, n, R¿1?, R¿2?, R¿3? et R¿4 ? étant indiquées dans les spécifications, qui sont des inhibiteurs de cystéine protéase comprenant, notamment, des inhibiteurs de cathepsines K, L, S and B. C. Ces composés conviennent pour traiter des maladies dans lesquelles l'inhibition de la résorption osseuse est indiquée telle que l'ostéoporose.

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