Cathepsin cysteine protease inhibitors

Details Cathepsin cysteine protease inhibitors Cathepsin cysteine protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 255/46 (2006.01) A61K 31/275 (2006.01)

Patent

CA 2589085

This invention relates to a novel class of compounds, diagrammed below, wherein R1, R2, R3, R4, R5, R6, R7, D and n are defined therein, which are cysteine protein inhibitors, including, but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone reportion is indicated, such as osteoporosis.

La présente invention concerne une nouvelle classe de composés représentés par la formule de l'invention, dans laquelle R1, R2, R3, R4, R5, R6, R7, D et n sont tels que définis dans les spécifications. Ces composés, qui sont des inhibiteurs de protéine cystéine, et notamment des cathepsines K, L, S et B, conviennent au traitement d'affections, et notamment de l'ostéoporose, dans lesquelles l'inhibition de la résorption osseuse est indiquée.

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