Cathepsin cysteine protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/36 (2006.01) A61K 31/277 (2006.01) A61K 31/4418 (2006.01) A61P 19/00 (2006.01) C07C 255/29 (2006.01)

Patent

CA 2548600

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

L'invention concerne une nouvelle classe de composés qui constituent des inhibiteurs des protéases à cystéine, qui comprend, de façon non exhaustive, les inhibiteurs des cathepsines K, L, S et B. Ces composés sont utiles pour le traitement de maladies pour lesquelles l'inhibition de la résorption osseuse est indiquée, par exemple l'ostéoporose.

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