Cathepsin d is an amyloidogenic protease in alzheimer's disease

Details Cathepsin d is an amyloidogenic protease in alzheimer's disease Cathepsin d is an amyloidogenic protease in alzheimer's disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 38/04 (2006.01) A61K 38/55 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2151927

Disclosed are methods for regulating formation of beta-amyloid protein with inhibitors of proteases specific for the Precursor to the Alzheimer's Disease beta-amyloid protein, such as inhibitors of aspartic protease, cathepsin D, and a chymotryptic-like serine protease; a method for detecting in vitro protease activity for molecules which possess specificity necessary for the degradation of the Amyloid Precursor Protein; assays for identifying inhibitors of proteases specific for the Amyloid Precursor Protein; and identified inhibitors and their use as therapeutics for the treatment of Alzheimer's Disease.

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