C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/29 (2006.01) C07C 317/22 (2006.01) C07C 317/40 (2006.01) C07D 241/04 (2006.01) C07D 333/10 (2006.01)
Patent
CA 2535366
This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.
La présente invention a trait à une nouvelle classe de composés de formule (I), dans laquelle R¿1?, R¿2?, R¿3? and R¿4? sont tels que définis dans la description, qui sont des inhibiteurs de la cystéine protéase, comprenant mais de manière non exclusive, des inhibiteurs des cathepsines K, L, S et B. Ces composés sont utiles pour le traitement de maladies dans lesquelles l'inhibition de la résorption osseuse est indiquée, telles que l'ostéoporose, l'arthrose et al polyarthrite rhumatoïde.
Bayly Christopher
Black Cameron
Mckay Daniel J.
Merck Frosst Canada & Co.
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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