Cathepsin propeptide and uses thereof

Details Cathepsin propeptide and uses thereof Cathepsin propeptide and uses thereof

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2643723

A method of inhibiting activity of a cathepsin L-like protease in cells or tissue and the use of the method in the treatment of disease such as cancer and inflammatory diseases is described. The method comprises administration of a cathepsin propeptide or a nucleic acid encoding a cathepsin propeptide. In particular embodiments, the propeptide is a Cathepsin S propeptide. Further, the use of propeptides having an Fc portion is described.

La présente invention concerne un procédé permettant d'inhiber l'activité d'une protéase semblable à la cathepsine L dans des cellules ou un tissu, ainsi que l'utilisation du procédé dans le cadre du traitement de maladies telles que le cancer et les maladies inflammatoires. Le procédé ci-décrit consiste à administrer un propeptide de cathepsine ou un acide nucléique codant pour un propeptide de cathepsine. Dans des modes de réalisation particuliers, le propeptide est un propeptide de la cathepsine S. La présente invention concerne en outre l'utilisation de propeptides comprenant une partie Fc.

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