C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 39/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2604036
Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members binds cathepsin S and inhibits its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associoated with excessive, deregulated or inappropriate angiogenesis.
L'invention concerne des éléments de liaison spécifiques, par exemple, des anticorps pouvant être utilisés pour traiter des maladies associées à l'activité de la cathepsine S. Lesdits éléments de liaison spécifiques se lient à la cathepsine S et inhibent son activité protéolytique. On peut utiliser ces éléments de liaison pour traiter des maladies, telles que le cancer, les maladies inflammatoires, les troubles neurodégénératifs, les troubles auto-immunes et d'autres maladies associées à une angiogénèse excessive, dérégulée ou inappropriée.
Burden Roberta
Johnston Jim
Olwill Shane
Scott Christopher
Walker Brian
Fusion Antibodies Limited
Gowling Lafleur Henderson Llp
LandOfFree
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