Cathepsin s inhibitors

Details Cathepsin s inhibitors Cathepsin s inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/66 (2006.01) A61K 31/4468 (2006.01) A61K 31/536 (2006.01) A61P 37/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2518728

This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such compounds and pharmaceutical compositions comprising them.

L'invention concerne des composés peptidyl de formule (I) et (II), actifs en tant qu'inhibiteurs de la cathepsine S, une protéase à cystéine. Les composés selon l'invention sont des inhibiteurs réversibles et sélectifs de la cathepsine S, et sont donc utiles dans le traitement des maladies auto-immunes et d'autres maladies. L'invention concerne également des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant.

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