Catheter for tissue dilatation and drug delivery

A - Human Necessities – 61 – M

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Details

A61M 25/10 (2006.01) A61M 29/02 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2217945

A combination dilatation and drug delivery device includes a flexible catheter (18,90), a drug delivery sheath (20,92) mounted to a distal end region of the catheter and a dilatation balloon (24) or other dilatation device (104) mounted to the catheter and contained within a compartment (52,100) formed by the sheath. The sheath is radially expandable by supplying a liquid therapeutic agent to the compartment under a moderate pressure. The dilatation balloon is expandable by providing a dilatation fluid to the balloon under a much higher pressure. The sheath can be formed of a highly elastic material or can be made quite thin, and in either case is mounted independently of the dilatation device. Thus when radially expanded, the sheath is moved into a conforming contact with surrounding vascular tissue. The conforming contact protects tissue and the therapeutic agent from exposure to blood, and more effectively confines the therapeutic agent to the intended treatment area. The sheath either is naturally porous or is provided with multiple pores, whereby the therapeutic agent perfuses through the sheath into the surrounding tissue.

Un dispositif double de dilatation et d'administration de médicaments comporte un cathéter souple (18, 90), une gaine d'administration de médicaments (20, 92) montée à une extrémité distale du cathéter et un ballonnet de dilatation (24) ou un autre dispositif de dilatation (104) monté sur le cathéter et placé à l'intérieur d'une chambre (52, 100) de la gaine. La gaine peut se dilater radialement en remplissant la chambre, sous pression modérée, d'un agent thérapeutique liquide. Le ballonnet de dilatation peut se dilater en l'alimentant d'un fluide de dilatation sous pression beaucoup plus élevée. La gaine peut être faite d'un matériau hautement flexible ou être très mince. Peu importe le cas, elle est installée indépendamment du dispositif de dilatation. Donc, lorsqu'elle est dilatée radialement, la gaine est placée de façon à épouser étroitement les tissus vasculaires avoisinants. Ce genre de contact prévient toute exposition au sang des tissus et de l'agent thérapeutique et confine ce dernier plus efficacement à la zone de traitement prévue. La gaine est naturellement poreuse ou est percée de multiples pores, ce qui permet à l'agent thérapeutique de passer à travers la gaine jusque dans les tissus avoisinants.

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