Cation-complexed polysaccharides

A - Human Necessities – 61 – K

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Details

A61K 47/36 (2006.01) A23L 1/304 (2006.01) A23L 1/308 (2006.01) A61K 31/715 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61P 1/12 (2006.01)

Patent

CA 2128160

CATION-COMPLEXED POLYSACCHARIDES Abstract of the Disclosure The present invention is a novel, water-insoluble, cation-complexed anionic polysaccharide that is readily dispersible into aqueous media to provide an ingestible composition having a low viscosity. An important aspect of the present invention is that it provides such compositions that are heat sterilizable. Furthermore, the water- insoluble, cation-complexed anionic polysaccharide of the present invention cause no or minor increases to the viscosity of such liquids that contain at least one member selected from the group consisting of proteins, peptides and amino acids. Another aspect of the invention concerns a method for administering an antidiarrheal composition to a human, said antidiarrheal composition comprising at least one water- insoluble, cation-complexed anionic polysaccharide dispersed in an aqueous medium. These compositions are useful as a nutritional means of improving gastrointestinal function including bowel function and increasing absorption of organic nutrients, inorganic nutrients and water by the gastrointestinal tract. In another aspect of the present invention is provided a novel method of preparing a water-insoluble, cation-complexed anionic polysaccharide comprising wetting a starting anionic polysaccharide with water to a total solids content of about 30 to 70%, adding a cation and then milling. In yet another aspect of the present invention is provided a composition comprising a water-insoluble, cation-complexed anionic polysaccharide. This invention also provides a low viscosity, feeding composition providing an individual's requirements for carbohydrates, proteins, lipids, vitamins, minerals and at least one substantially water-insoluble, cation-complexed anionic polysaccharide in an aqueous medium. This same composition may be prepared in a dehydrated state and then subsequently rehydrated when ready for use.

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