C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61P 31/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2399668
This invention relates to an antimicrobial compound which is (a) a peptide having a length of 8-50 amino acids, a net charge of at least four, a hydrophobic moment as a beta sheet which is at least 0.2 higher than its hydrophobic moment as an alpha helix, and having dectectable membrane disrupting activity against at least one microbial pathogen, and substantially no membrane disrupting activity against mammalian cells, or (b) a peptoid, petidomimetic or nonpeptidic analogue of a peptide according to (a) above. And to antimicrobial use thereof.
L'invention concerne un composé antimicrobien consistant en (a) un peptide présentant une longueur de 8-50 acides aminés, une charge nette d'au moins 4, un moment hydrophobe sous forme de feuillet bêta qui est au moins 0,2 fois supérieur à son moment hydrophobe en tant qu'hélice alpha, et exerçant également une activité détectable de rupture de membrane contre au moins un pathogène microbien et pratiquement aucune activité de rupture de membrane contre des cellules mammifères, ou (b) un analogue peptoïde peptidomimétique ou non peptidique d'un peptide d'après (a). Elle concerne également l'utilisation antimicrobienne de ce composé.
Ohio University
Smart & Biggar
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